TUhjnbcbe - 2021/6/18 9:30:00
Workfromanimalmodelssuggeststhatretinaldefocus(orvisualblur)initiatesasignalingcascadethatleadstoanumberofcellularandbiochemicalchangesintheretinaandtheretinalpigmentepithelium(RPE),whichsignalchangestothechoroid,andeventuallythesclera,leadingtoalterationsintheoverallgrowthandrefractivestateoftheeye(Fig.4.7).Theretinaisanintegralpartofthisvisualsignalingasitisthefirstlayerofphotosensoryneuronsthatdetectdefocus.Furthermore,ocular